Translational Phototherapeutics Laboratory

Publications

1. 🐶 Photodynamic therapy management of canine mammary gland tumour with wireless upconversion implant. View (2025)
   Demonstrated a wireless implant for treating mammary tumors in dogs via photodynamic therapy. DOI: 10.1002/VIW.20250020

2. 🌡️ Nanothermometry for Cellular Temperature Monitoring and Disease Diagnostics. Interdisciplinary Medicine2(2): e12096 (2024)
   Explored nanoscale thermometers for monitoring cellular temperature in disease contexts. DOI: 10.1002/inmd.12096

3. 🌡️ Nanothermometry for cellular temperature monitoring and disease diagnostics. Interdisciplinary Medicine2(2): e20230059 (2024)
   Advanced precision nanothermometry tools for diagnostics at the cellular level. DOI: 10.1002/INMD.20230059

4. 🎯 PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular Cancer22(1):138 (2023)
   Reviewed therapeutic opportunities targeting a key cancer signaling pathway. DOI: 10.1186/s12943-023-01827-6

5. ✨ SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS Nano 17(12):11593–11606 (2023)
   Created a bright implant enabling light-activated cancer therapy deep inside tissue. DOI: 10.1021/acsnano.3c01916

6. 🌍 The global impact of COVID-19 on abortion care. Heliyon 9(5): e16094 (2023)
   Analyzed how COVID-19 disrupted access to abortion services worldwide. DOI: 10.1016/j.heliyon.2023.e16094

7. 🧠 Biomimetic nanotherapeutics for targeted drug delivery to glioblastoma multiforme. Bioengineering & Translational Medicine 8(3): e10483 (2023)
   Designed nanomedicines that mimic biology to target aggressive brain cancer. DOI: 10.1002/btm2.10483

8. 🩸 COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines 11(4):1181 (2023)
   Linked COVID-19–induced lipid changes to risks of clotting. DOI: 10.3390/biomedicines11041181

9. 📱 Effects of mobile health interventions on health-related outcomes in older adults with type 2 diabetes: A systematic review and meta-analysis. Journal of Diabetes 15(1):47–57 (2023)
   Showed mobile health apps can improve outcomes in elderly diabetes patients. DOI: 10.1111/1753-0407.13346

10. ♀️ Unraveling female reproductive senescence to enhance healthy longevity. Cell Research 33(1):11–29 (2023)
    Examined mechanisms of reproductive aging to promote women’s healthspan. DOI: 10.1038/s41422-022-00718-7

11. 🔆 Application of Optogenetics for Muscle Cells and Stem Cells. Advances in Experimental Medicine and Biology1293:359–375 (2021)
    Reviewed how optogenetics can control muscle and stem cell behavior. DOI: 10.1007/978-981-15-8763-4_23

12. 🧠 A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced Materials32(29): e2001459 (2020)
    Developed a flexible implant for wireless light-driven brain cancer therapy. DOI: 10.1002/adma.202001459

13. 🧬 Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics. Neuromolecular Medicine22(1):139–149 (2020)
    Showed optogenetic tools can trigger neural stem cells to form new neurons. DOI: 10.1007/s12017-019-08573-3

14. ✨ Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation. Advanced Materials 31(41): e1803474 (2019)
    Enhanced the range of nanoparticles available for brain stimulation with light. DOI: 10.1002/adma.201803474

15. 🔎 Upconversion amplification through dielectric superlensing modulation. Nature Communications 10:1391 (2019)
    Used dielectric superlenses to boost light upconversion signals. DOI: 10.1038/s41467-019-09345-0

16. 🔧 Fibro-Neuronal Guidance on Common, 3D-Printed Textured Substrates. IEEE Transactions on Nanobioscience 18(2):226–229 (2019)
    3D-printed surfaces guided interactions between neurons and fibroblasts. DOI: 10.1109/TNB.2019.2905469

17. 🧠 Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy. Materials Horizons 6(2):311–317 (2019)
    Developed nanoparticles for tumor margin detection and laser therapy in brain cancer. DOI: 10.1039/c8mh00946e

18. 🌟 All-inorganic perovskite nanocrystal scintillators. Nature 561(7721):88–93 (2018)
    Introduced perovskite nanocrystals as bright radiation detectors. DOI: 10.1038/s41586-018-0451-1

19. 🧊 Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model. The Spine Journal 18(3):507–514 (2018)
    Tested cooling therapy as a protective strategy after spinal cord injury. DOI: 10.1016/j.spinee.2017.10.066

20. 🔦 Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science359(6376):679–684 (2018)
    Pioneered wireless deep-brain optogenetic stimulation with near-infrared light. DOI: 10.1126/science.aaq1144

21. 🧪 Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1β. Scientific Reports 7(1):13988 (2017)
    Uncovered protective gene programs in astrocytes activated by inflammation. DOI: 10.1038/s41598-017-13174-w

22. 🔐 Binary temporal upconversion codes of Mn²⁺-activated nanoparticles for multilevel anti-counterfeiting. Nature Communications 8:899 (2017)
    Designed nanoparticles with unique light codes for secure authentication. DOI: 10.1038/s41467-017-00916-7

23. 🧲 Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Scientific Reports 7:6743 (2017)
    Showed static magnetic fields can boost myelin-producing cell growth. DOI: 10.1038/s41598-017-06331-8

24. 💊 Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery. Advanced Materials 29(18) (2017)
    Created multifunctional nanocrystals for imaging and targeted drug release. DOI: 10.1002/adma.201700244

25. 🧪 Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes. Angewandte Chemie International Edition 56(15):4165–4169 (2017)
    Developed light-based nanosensors to monitor liver toxicity in real time. DOI: 10.1002/anie.201612020

26. 🔁 Direct Conversion Through Trans-Differentiation: Efficacy and Safety. Stem Cells and Development26(3):154–165 (2017)
    Evaluated safety and effectiveness of reprogramming cells into new lineages. DOI: 10.1089/scd.2016.0174

27. 🔬 Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging. Chemistry – A European Journal 22(31):10801–10807 (2016)
    Engineered nanocrystals optimized for deep tissue optical imaging. DOI: 10.1002/chem.201602514

28. 🧬 A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation. Regenerative Medicine 11(2):181–191 (2016)
    Reviewed stem cell reprogramming and differentiation for regenerative therapy. DOI: 10.2217/rme.16.5

29. 🧠 Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca²⁺ channels. Development, Growth & Differentiation 56(8):583–594 (2014)
    Found calcium channels play key roles in adult neural stem cell maturation. DOI: 10.1111/dgd.12158